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      杭州微米生物科技有限公司是一家以创新型平台驱动的高科技企业。公司集研发、生产与技术服务于一体,志在成为行业的开拓者与引领者。公司自成立以来深耕蛋白质组学产业,以生物质谱为核心工具,结合抗体试剂产品,整合生物化学、免疫学、分子生物学、生物信息学等多领域交叉学科,搭建了“高通量蛋白质组分析+高特异性抗体开发”的有机整合业务布局,是行业内提供涵盖蛋白质“发现”、“验证”以及“检测”的蛋白质组分析整体解决方案的先行者。
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BIBLIOGRAPHY
Titles Journal
UFMylation maintains tumour suppressor p53 stability by antagonizing its ubiquitinationNature Cell Biology
A novel risk signature for predicting brain metastasis in patients with lung adenocarcinomaNeuro Oncology
Phosphorylation of human glioma-associated oncogene 1 on Ser937 regulates Sonic Hedgehog signaling in medulloblastomaNature communication
Hypoxia-inducible Factor-1α directs renal regeneration induced by decellularized scaffoldsBiomaterials
Dysregulation of PD-L1 by UFMylation imparts tumor immune evasion and identified as a potential therapeutic targetPNAS
Pathogenic fungi neutralize plant-derived ROS via Srpk1 deacetylationthe EMBO Jurnal
Lactate enhances NMNAT1 lactylation to sustain nuclear NAD+ salvage pathway and promote survival of pancreatic adenocarcinoma cells under glucose-deprived conditionsCancer Letters
Plant PR1 rescues condensation of the plastid iron-sulfur protein by a fungal effectorNature Plants
Sir2-mediated cytoplasmic deacetylation facilitates pathogenic fungi infection in host plantsNew Phytologist
TSPAN6 reinforces the malignant progression of glioblastoma via interacting with CDK5RAP3 and regulating STAT3 signaling pathwayInt. J. Biol. Sci.
E3 ubiquitin ligase SYVN1 is a key positive regulator for GSDMD-mediated pyroptosisCell Death & Disease
Crotonylated BEX2 interacts with NDP52 and enhances mitophagy to modulate chemotherapeutic agent-induced apoptosis in non-small-cell lung cancer cellsCell Death & Disease
Duality of H2O2 detoxification and immune activation of Ralstonia solanacearum alkyl hydroperoxide reductase C (AhpC) in tobaccoInt. J. Biol. Macromol.
Global analysis of lysine succinylation in patchouli plant leavesHorticulture Research
FolIws1-driven nuclear translocation of deacetylated FolTFIIS ensures conidiation of Fusarium oxysporumCell Reports
Triacanthine enhances the sensitivity of colorectal cancer cells to 5-fluo rouracil by regulating RRM2Phytomedicine
Plant iron status regulates ammonium-use efficiency through protein N-glycosylationPlant Physiology
The decrotonylase FoSir5 facilitates mitochondrial metabolic state switching in conidial germination of Fusarium oxysporumeLife
Quantitative Proteomic Analysis Reveals Important Roles of the Acetylation of ER-Resident Molecular Chaperones for Conidiation in Fusarium oxysporumMol Cell Proteomics
Quantitative Phosphoproteomic and Metabolomic Analyses Reveal GmMYB173 Optimizes Flavonoid Metabolism in Soybean under Salt StressMol Cell Proteomics
Maize (Zea mays L.) planted at higher density utilizes dynamic light more efficientlyPlant, Cell & Environment
Comparative iTRAQ-based proteomic analysis provides insight into a complex regulatory network of Pogostemon cablin in response to exogenous MeJA and EthrelIndustrial Crops & Products
Proteomic and Phosphoryproteomic Investigations Reveal that Autophagy-Related Protein 1, a Protein Kinase for Autophagy Initiation, Synchronously Deploys Phosphoregulation on the Ubiquitin-Like Conjugation System in the Mycopathogen Beauveria bassianamSystems
Global Analysis of Lysine Lactylation of Germinated Seeds in WheatInt. J. Mol. Sci.
Identification of lysine-lactylated substrates in gastric cancer cellsiScience
Essential role of Rpd3-dependent lysine modification in the growth, development and virulence of Beauveria bassianaEnvironmental Microbiology
Pleiotropic effects of Ubi4, a polyubiquitin precursor required for ubiquitin accumulation, conidiation and pathogenicity of a fungal insect pathogenEnvironmental Microbiology
Large-scale analysis of protein crotonylation reveals its diverse functions in Pinellia ternataBMC Plant Biology
Proteomic analysis of protein lysine 2-hydroxyisobutyrylation (Khib) in soybean leavesBMC Plant Biology
Proteomic analysis of the regulatory networks of ClpX in a model cyanobacterium Synechocystis sp. PCC 6803Frontiers in Plant Science
Systematic Analysis of Lysine Lactylation in the Plant Fungal Pathogen Botrytis cinereaFrontiers in Microbiology
Global analysis of lysine 2‑hydroxyisobutyrylation in wheat rootScientific Reports
Global analysis of lysine acetylation in soybean leavesScientific Reports
Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinomaProteomics 
Titles Journal
Phosphorylation of human glioma-associated oncogene 1 on Ser937 regulates Sonic Hedgehog signaling in medulloblastoma Nature communication
Dysregulation of PD-L1 by UFMylation imparts tumor immune evasion and identified
as a potential therapeutic target
PNAS
Identification of lysine-lactylated substrates in gastric cancer cells iScience
Human UFSP1 translated from an upstream near-cognate initiation codon functions as an active UFM1-specific protease J. Biol. Chem.
Quantitative Proteomic Analysis Reveals Important Roles of the Acetylation of ER-Resident Molecular Chaperones for Conidiation in Fusarium oxysporum Mol Cell Proteomics
Proteomic and Phosphoryproteomic Investigations Reveal that Autophagy-Related Protein 1, a Protein Kinase for Autophagy Initiation, Synchronously Deploys Phosphoregulation on the Ubiquitin-Like Conjugation System in the Mycopathogen Beauveria bassiana msystems
The decrotonylase FoSir5 facilitates mitochondrial metabolic state switching in conidial germination of Fusarium oxysporum eLife
UFMylation maintains tumour suppressor p53 stability by antagonizing its ubiquitination Nature cell biology
Pleiotropic effects of Ubi4, a polyubiquitin precursor required for ubiquitin accumulation, conidiation and pathogenicity of a fungal insect pathogen Environmental Microbiology
Global analysis of lysine succinylation in patchouli plant leaves Horticulture Research
Essential role of Rpd3-dependent lysine modification in the growth, development and virulence of Beauveria bassiana Environmental Microbiology
Global analysis of protein lysine succinylation profiles in common wheat BMC Genomics
Pathogenic fungi neutralize plant-derived
ROS via Srpk1 deacetylation
the EMBO Jurnal
Global profiling of protein lysine lactylation and
potential target modified protein analysis in hepatocellular carcinoma
Proteomics 
Acetylation of a fungal effector that
translocates host PR1 facilitates virulence
eLife
Sir2-mediated cytoplasmic deacetylation facilitates pathogenic fungi infection in host plants New Phytologist
Lactate enhances NMNAT1 lactylation to sustain nuclear NAD+ salvage pathway and promote survival of pancreatic adenocarcinoma cells under glucose-deprived conditions Cancer Letters
Global Analysis of Lysine Lactylation of Germinated Seeds in Wheat Int. J. Mol. Sci.
Maize (Zea mays L.) planted at higher density utilizes dynamic light more efficiently Plant Cell Environ
Structural and functional regulation of Chlamydomonas lysosome-related organelles during environmental changes Plant Physiol
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